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However, supplementation should always be part of a broader, comprehensive management strategy that includes aggressive pacing, nervous system regulation, and targeted medical care
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Kanazawa I, Tanaka KI, Sugimoto T
van Erven L, Schalij MJ (2010) Amiodarone: an effective antiarrhythmic drug with unusual side effects
Secondly, since cardiomyocytes are easily affected by free iron overload, the release of excess free iron during ferroptosis would result in up-regulation of transferrin receptor (TFR) and down-regulation of ferritin, promoting cardiomyocyte cell death through mitochondrial VDAC2/3 or membrane lipid peroxidation through Fenton reaction to induce myocardial edema and dysfunction (Liu et al., 2018)
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