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4.1.5 Specific inhibitors of dihydroceramide desaturase 1 Another possible therapeutic target is the enzyme dihydroceramide desaturase 1 (DES1), which is involved in ceramide production (116)
Other serious risks include acute pancreatitis (reported as 0.23 cases per 100 patient-years), acute gallbladder disease, hypoglycemia (particularly when combined with insulin or sulfonylureas), acute kidney injury (often secondary to dehydration from gastrointestinal effects), and hypersensitivity reactions
While on a GLP-1, hydration needs to become intentional, not passive, says Priya Jaisinghani, MD, an endocrinologist and obesity medicine specialist at NYU Langone in New York City
