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A more recent review describes this as a bidirectional relationship: GLP-1 drugs can shift the microbiome, and a person's existing microbiome may also predict how well they respond to the medication ( Frontiers in Endocrinology , 2026)
ICH Q7 discusses primary and secondary reference standards and notes that secondary reference standards should be compared against a primary reference standard before first use [15]
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5 Concluding Remarks It is believed that GLP-1RAs promote weight loss mainly because of their inhibitory effect on food intake [42]
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