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Looking ahead, the accumulating body of evidence supporting the cardiovascular benefits of GLP-1 RAs highlights the need to integrate them more widely into routine clinical practice
10.1042/cs1030339 45
Many people with deep pockets that are on the drug are using it as a quicker way to lose weight instead of the morbid obesity and diabetes prevention it was originally prescribed for
In addition to these findings on atherosclerotic plaque formation, GLP-1R agonists prevented the increase in plasminogen activator inhibitor type-1 (PAI-1) and vascular cell adhesion molecule-1 (VCAM-1) gene expression in response to TNF- or hyperglycemia in HUVEC through PKA pathway [24],[70]
220 Hypoxia-inducible factor-3 (HIF3A) belongs to the hypoxia-inducible factors family (HIFs) that play important roles in the pathogenesis of obesity-induced IR, adipose tissue-inflammation and the etiology of obesity related disease
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