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From Obesity to Metabolic Health: Why Retatrutide Is a Game-Changer Abstract Obesity and type 2 diabetes have become global health crises, fueling complications such as cardiovascular disease, fatty liver disease, and metabolic syndrome

But where semaglutide acts on one receptor (the glucagon-like peptide-1, or GLP-1, receptor), and tirzepatide on two (GLP-1 and the gastric inhibitory polypeptide, or GIP, receptors), retatrutide has been nicknamed Triple G for its ability to work on three hormone receptors (those for GLP-1 and GIP, as well as the glucagon, or GCG, receptor)

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Practical Ways to Support Natural GLP-1 Support natural GLP-1 with habits that favor L-cell stimulation: prioritize protein at meals, include viscous fiber from oats, legumes, or psyllium as tolerated, avoid extreme grazing if it blunts distinct meal signals, and keep resistance training in the plan for insulin sensitivity