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This article was partially sponsored by the National High-Level Hospital Clinical Research Funding (2022-PUMCH-C-049 and 2022-PUMCH-A-237) and Beijing Students Funding for Innovation and Entrepreneurship Training Program (2024dcxm034)

Studies have documented MC receptor binding at all five subtypes, with particular focus on MC1R-mediated pigmentation responses and MC4R-mediated CNS pathway modulation in rodent models

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