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Intrinsic DILI is predictable and observed in preclinical studies 57, 58
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(5) Kopchick JJ, Berryman DE, Puri V, Lee KY, Jorgensen JOL
Metformin, the medicine in Metformin tablets, can cause a rare, but serious, side effect called lactic acidosis (a build-up of lactic acid in the blood) that can cause death
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