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Mechanistically, the depletion of METTL14 disrupts m6A methylation of the suppressor of cytokine signaling 1 (SOCS1) transcript, reducing its recognition by the m6A reader protein YTHDF1
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The same shuttling system can also export excess acetylcarnitine out of the mitochondria to limit inhibition of pyruvate dehydrogenase and spare the pool of free CoA necessary for other molecules
Natural plant polysaccharides can effectively regulate gut microbiota disorders and intervene in the development of depression through MGBA
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