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The results were striking: Nearly half cut their pain days in half

Compared with clinical trials [7,8,9,10,11,12,13,14,15,16,17,18], we observed a higher rate of treatment discontinuation for both GLP-1 receptor agonists and SGLT2 inhibitors

The Liver-selective TR knockout mice (LTRKO) were generated by cross-breeding of TR Floxed mice with mice harboring Cre-recombinase under the control of the albumin promoter (Alb-Cre mice)