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Fold change in DiI-LDL uptake by melanoma PDX cell suspensions treated with heparinases and chondroitinase (1 U/mL of both, dark blue) relative to untreated samples (grey)
The HUA group received daily intraperitoneal injection of potassium oxonate (PO) 350 mg/kg and oral gavage of hypoxanthine (HX) 450 mg/kg, while the blank group received the same amount of solvent
N Eng J Med
Laboratory studies demonstrate that ES2 peptides show 3-7 times more potent senolytic activity than FOXO4-DRI in both in vitro and in vivo experimental systems, while CPP-CAND demonstrates approximately 1.2-fold higher selectivity despite shorter peptide length
41589_2021_915_MOESM3_ESM.mpeg Supplementary Video 1 Representative movie for 100 ns MD simulation of WT GPX4
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