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IGF-1 LR3 is modified at two positions (N-terminal 13-amino-acid extension and Arg3 substitution) to substantially reduce IGFBP-3 binding, extending preclinical activity duration well beyond the roughly 10 to 12 minutes seen with unbound native IGF-1
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Anim Reprod Sci 58(3-4):261272 Humbel RE (1990) Insulin-like growth factors I and II
International Journal of Health & Chiropractic, 20(2), 18
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