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Hsu YC, Huang HP, Yu IS, Su KY, Lin SR, Lin WC, Wu HL, Shi GY, Tao MH, Kao CH, Wu YM, Martin PE, Lin SY, Yang PC, Lin SW
Microglial ferroptosis has been shown to induce neurotoxic astrocytes through pro-inflammatory signaling (such as IL-6 and TNF-), and ferroptosis-related genes including ACSL4 and GPX4 are highly enriched in microglia within HD lesions
According to the company and consistent with published pre-clinical literature, it has been studied in animal models for pre-clinical signals related to the gastrointestinal environment, inflammatory responses in the GI tract, and tissue-related processes in tendon and joint contexts - all per pre-clinical animal data, not established human clinical outcomes
2017 Jan;137(1):58-62
Fish oil and antioxidants alter the composition and function of circulating mononuclear cells in Crohn disease
