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Specialized DNA polymerases are ectopically overexpressed in several cancers, can function as an oncogene and enhance mutations induced by DNA damage 44,45,46
This trial was the basis for Zepbound's weight management approval
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Common side effects include: Nausea and occasional vomiting Diarrhoea or constipation Stomach pain and bloating Acid reflux or heartburn Fatigue To minimise these side effects, doctors start patients on the lowest possible dose and gradually increase it over several months
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