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A common research framing is a defined block (often 812 weeks) followed by an off period, rather than indefinite continuous use a conservative default given the absence of long-term human data

A dose of 1,000 mcg is often used, mainly for severe cases or initial treatment

Animal studies have shown that when beta-3 adrenergic receptors were genetically removed, chronic AOD-9604 treatment produced no changes in weight or lipolysis, confirming the importance of this pathway

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