Factors such as peptide concentration, formulation stability, delivery system, and manufacturing quality can influence performance
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Moreover, they influence immune recruitment and migration by altering the synthesis of chemokines and adhesion molecules (271, 276)
Preclinical studies have described the role of Vitamin E in AD: it seems to reduce transepidermal water loss (TEWL), which is associated with AD pathogenesis, and to induce the expression of the transglutaminase-1 gene, involved in terminal differentiation of keratinocytes and in the formation of the stratum corneum (8385)