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The profound, debilitating fatigue experienced in ME/CFS and Long COVID is fundamentally different from normal tiredness
Genetic factors, including those affecting neurotransmitter metabolism and receptor expression and function, are moderately heritable (up to 45%) and may account for some of the risk
It is primarily investigated in models of obesity, muscle wasting (sarcopenia), and metabolic bioenergetics
Conclusion The combination of NAD+ and 5-Amino-1MQ is still relatively new, but its potential is groundbreaking
Allometric scaling: Using the FDA's standard body surface area conversion (rat dose x 0.162), the human equivalent range is roughly 110-560 mcg/day -- which is where the community's 250-500 mcg/day window comes from
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