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Black Box Warning Zepbound carries a black box warning due to findings in animal studies where GLP-1 medications, like Tirzepatide, have been associated with an increased risk of thyroid C-cell tumors

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They also play roles in PANS (Pediatric Acute-onset Neuropsychiatric Syndrome), depression, bipolar disorder, and anxiety disorders

PYY is a gut hormone with a length of 36 amino acids, although its major form is truncated at the N-terminus to give PYY 3-36 88

Takeaways More long-term study is needed, but its generally OK to drink alcohol while taking GLP-1 drugs like semaglutide (Ozempic) for weight loss