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These citations are context, not medical advice, proof of eligibility, or a claim that every study applies to every patient

Penetration is limited compared to injection, but topical application is still clinically meaningful for surface skin remodeling when used consistently

This difference in molecular weight impacts their penetration ability in the skin, with glycolic acid being smaller and able to penetrate deeper and more quickly, while mandelic acid, being larger, is more gentle and works at the skins surface

1991 Copper peptide effects on follicle-derived cell proliferation (PubMed) Pyo HK et al