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Mitochondria-targeted inhibitors of the human SIRT3 lysine deacetylase

Not for human consumpt

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Notably, heatmap showing the expressions of significantly expressed genes from the pathways of interest was generated by the R package ggplot2 using the metric FPKM, and was colored by the z-score that was computed from the average FPKM of samples in each stage by subtracting the value of the average FPKM in the four stages then dividing by the standard deviation

Before the experiments, the worms were rinsed off the growth plates and washed three times in CTM (5 mM potassium phosphate, pH 6.0, 1 mM CaCl 2 , 1 mM MgSO 4 ) to remove bacteria