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Patients receiving tirzepatide 10 mg or 15 mg achieved mean weight reductions of 9.3 kg and 11.2 kg respectively over 40 weeks, demonstrating that tirzepatide's weight loss efficacy remains substantial when added to existing metformin therapy
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CIT significantly improved endothelial function, forearm microvascular reactivity (TOI indices), plasma arginine levels, and calf muscle strength (both absolute and body-weightnormalized) compared with placebo
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