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The naturally occurring ligands for PPAR- are leukotriene B 4 (LTB 4 , see the Eicosanoid Metabolism: Prostaglandins, Thromboxanes, Leukotrienes, and Lipoxins page), unsaturated fatty acids and oxidized components of VLDL and LDL

The relevant limit used was 0.25 EU/mL

PMID 10469335

In addition, 50 M DPA significantly reduced BV2 cell viability after stimulation with 100 ng/mL LPS, demonstrating that n-3 DPA may inhibit microglia-NF-B and MAPK p38 by balancing microglia M1 and M2 polarization (70)

Comparative Effect Sizes Overall, copper peptides perform comparably to mid-tier cosmetic actives but below prescription-level retinoids