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Research presented at the 2025 American Academy of Orthopaedic Surgeons meeting found GLP-1 users had approximately 30% higher rates of osteoporosis compared to non-users, and a 2024 phase 2 trial published in eClinicalMedicine showed increased bone resorption markers and lower bone mass at the spine and hip in the semaglutide group versus placebo after 52 weeks
Side Effects and Safety of GLP-1 Medications GLP-1 medicines commonly cause digestive symptoms and may pose rare risks
Women tend to get thyroid cancer in their 40s and 50s, while men who get it are usually in their 60s or 70s
Clinical studies demonstrate that compounded GLP-1 formulations maintain bioavailability and efficacy equivalent to brand-name counterparts when sourced from licensed 503A facilities
High-dose infusions may help reduce fatigue and support the immune system
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