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doi: 10.1161/ATVBAHA.118.312054 134 SunXJiaoXMaYLiuYZhangLHeYet al

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The efficacy estimand demonstrated that 51.8%, 62.8%, and 73.3% of participants taking 5 mg, 10 mg, and 15 mg doses, respectively, achieved the resolution of MASH without any fibrosis worsening on liver histology at 52 weeks

Examination of individual plots of plasma d 3 -TMAO production from oral d 3 -l-carnitine challenges among vegans/vegetarians ( n = 7) demonstrated that the mean increase observed was driven by only a subset ( n = 3) of subjects, with over half ( n = 4) of the vegans/vegetarians demonstrating essentially no metabolic capacity to convert oral d 3 -l-carnitine into d 3 -TMAO even after months of l-carnitine supplementation (Supplemental Figure 3)