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Methods Retrospective study utilizing data from a federated research network (TriNetX)

Most research suggests protein targets of 1.0-1.2 grams per kilogram of body weight, or approximately 0.5 grams per pound, provide adequate support during weight loss

Similar patterns emerged with semaglutide

How oral and injectable semaglutide compare for weight loss An article from the Expert Review of Endocrinology & Metabolism shows that people taking injectable semaglutide lose slightly more weight than those on oral medicines

Slim Transformation Oct 21, 2025 4 min read People sometimes call a plateau tolerance, but classic drug tolerance isnt the main issue here