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Samudio I, Konopleva M, Jr HN, Y-X S, McQueen T, Hsu T, Evans R, Andreeff M
Treatment of breast cancer cell lines with 28-homocastasterone (28-homoCS) and 24-epibrassinolide (24-epiBL) has been associated with reduced expression of cyclins involved in the G1 phase of the cell cycle
Cagrilintide, the second generation (2020s) Novo Nordisk took the Pramlintide concept and applied the same half-life extension strategy that they used with Semaglutide: Kept the proline substitutions (anti-amyloid) Added a C20 fatty diacid via a -Glu linker to a lysine residue, albumin binding Additionally stabilized the N- and C-terminal positions Result: Cagrilintide with a half-life of 6.6 days (vs 50 minutes for Pramlintide)
Nuclear DNA content of muscle cells in experimental myotonia
Stanton McHardy and Hua-Yu Leo Wang) at the Center for Innovative Drug Discovery, University of Texas San Antonio for the synthesis and supply of scaled batches of 5-amino-1-methylquinolinium
