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The recommended daily intake of B12 is between 2.4 and 2.8 mcg, but its low absorption rate is the reason for such high dosages in supplements (NIH, 2020)
This complete absence of tolerability-driven discontinuations indicates that even when side effects occurred, they were sufficiently mild that participants chose to continue treatment
It does not cause photosensitivity (unlike retinoids), does not thin the skin (unlike corticosteroids), and does not require a tolerance-building period
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