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Additionally, your body can synthesize niacin from the amino acid tryptophan

Although current human data remain largely associative and causality has yet to be firmly established, accumulating preclinical and clinical studies suggest that baseline microbiome composition may modify therapeutic responsiveness

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A large case-control study found increased consumption of niacin, along with antioxidant nutrients, to be associated with decreased incidence of oral (mouth), pharyngeal (throat), and esophageal cancers in northern Italy and Switzerland