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Available from: Deanfield J, Verma S, Scirica BM, Kahn SE, Emerson SS, Ryan D et al (2024) Semaglutide and cardiovascular outcomes in patients with obesity and prevalent heart failure: a prespecified analysis of the SELECT trial
This is what distinguishes it mechanistically from earlier incretin-based agents, and it should be described as a designed mechanism that is still being characterized in trials rather than a fully settled clinical story
One significant study, called the STEP program, comprised four separate trials involving over 4,500 participants
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