10.1016/j.canep.2012.06.002 Cancer Epidemiol
Oxygen consumption (VO 2 ), carbon dioxide production (VCO 2 ), RER, energy expenditure (kcal h 1 ) and locomotor activity (cm s 1 ) were recorded and collected in 15 min bins
Diet and exercise remain the foundation every other intervention is built on, and they meaningfully improve obesity-related conditions such as hypertension and type 2 diabetes
Additionally, ferroptosis also plays a significant role in the onset and progression of female ovarian dysfunction, and it may induce ovarian dysfunction, damage pre-implantation embryos, reduce endometrial receptivity, and increase the crosstalk between diseases associated with subfertility [62, 63]
Epitalon is mechanistically robust, translationally immature, but positioned as a serious contender in future longevity protocols