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Santhosh C

Frystyk J, Skjaerbaek C, Vestbo E, Fisker S, Orskov H

However, LIRA led to a notable downregulation of Nox-1 mRNA ( p = 0.030) and a reduction in ET-1 protein expression ( p = 0.044)

in Value in Health modeled lifetime costs and quality-adjusted life years (QALYs) for three strategies: Indefinite semaglutide treatment 1-year treatment followed by discontinuation No pharmacotherapy (behavioral intervention only) For patients who lost 15%+ body weight on treatment, indefinite continuation was cost-effective at a willingness-to-pay threshold of $100,000 per QALY, primarily due to reduced diabetes and cardiovascular disease costs