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This could potentially lead to changes in thyroid hormone levels in the blood

On the other hand, most observations suggest that alpha cells in individuals with obesity and type 2 diabetes do exactly what they are supposed to do: glucose inhibits glucagon secretion (although this may be delayed [26] and/or depend on the route of glucose administration [27]), while proteins/amino acids stimulate secretion [28]

This is a major shift from just glycemic-centric treatment to including organ-protective drugs

More serious but rare side effects include pancreatitis, kidney issues, allergic reactions, and possible thyroid tumors (seen in animal studies)

In clinical trials, patients taking Zepbound lost over 20% of their body weight on average