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Flaxseeds Flaxseeds are rich in alpha-linolenic acid, a type of omega-3 fatty acid, and fiber
glucagon-like peptide-1 receptor agonists (GLP-1 RAs) ( 1) 1 GLP-1 RAs 1 GLP-1 RAs 2 GLP-1 Receptor GLP-1 Receptor (GLP-1R) (pleiotropic effects) GLP-1 RAs GLP-1R GLP-1R : GLP-1R (-cells) GLP-1 (glucose-dependent insulinotropic action) : GLP-1R sinoatrial node 2 10 GLP-1 RAs : GLP-1R paraventricular nucleus arcuate nucleus hypothalamus, nucleus tractus solitarius area postrema : GLP-1R (natriuresis) (nephroprotection) : GLP-1R Brunners glands myenteric plexus macrophages T cells GLP-1RAs (atherosclerosis): GLP-1R atherosclerotic plaques GLP-1R macrophages macrophages foam cells : nitric oxide (NO) : GLP-1RAs atherosclerotic plaques Nuclear Factor-B (NF-B): Interleukin-6 (IL_6) Tumor Necrosis Factor-alpha (TNF- ) macrophage (macrophage polarization): macrophage M1 M2 : GLP-1R (tubular cells) podocyte ferroptosis: GLP-1 RAs ferroptosis ferroptosis : GLP-1 RAs Transforming growth factor-(TGF-) : (natriuresis) (hyperfiltration) GLP-1 RAs SGLT2 inhibitors GLP-1 RAs Sodium-glucose cotransporter-2 (SGLT-2) inhibitors LEADER: liraglutide MACE ( ) 13 22 15 SUSTAIN-6: semaglutide MACE 26 39 HARMONY Outcomes: albiglutide MACE 22 6 REWIND: dulaglutide (primary prevention) 31 dulaglutide MACE 12 (4 ) FLOW trial: semaglutide semaglutide 24 (eGFR) GLP-1 RAs LEADER HbA1c (urinary albumin-creatinine ratio
Possible allergic reaction: Trouble breathing, facial swelling, or widespread hives requires urgent medical care
These two Peptides are often combined based on the fact that together they work way better than each on their own
Local delivery of corticosteroids in clinical ophthalmology: A review
