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Heavy metals (including lead, cadmium, mercury, and the metalloid arsenic) are persistent in the environment and have documented potential for serious health consequences

Compounding is defined as the preparation of a medication to meet the unique needs of a patient that cannot be met with an FDA-approved drug

The FDA concern is not just lack of approval

Reactive oxygen species accumulation in mitochondria could also be influenced by PTM of respiratory complexes (Taylor et al., 2003