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Besides classical antioxidant effects, dietary phenolic compounds or metabolites thereof have been discussed as modulators of DNA transcription based on interaction with transcription factors such as Nf-B (35, 36) or ligand-dependent transcription factors like the aryl hydrocarbon receptor (37) or peroxisome proliferator-activated receptors (38)

Strategies that may reduce side effects include: Eating smaller meals Avoiding high-fat or heavy foods Maintaining hydration Following the prescribed titration schedule Serious but Rare Risks Serious side effects are uncommon but may include: Pancreatitis Gallbladder disease Severe dehydration Kidney complications (often related to dehydration) There is also a boxed warning regarding thyroid C-cell tumors observed in animal studies

The +C Vit Brightening Perfector formula The texture of the Pixi Beauty +C Vit Brightening Perfector is that of a thick cream