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In the process of denervation, muscle proteins associated with proteolysis, including atrogin-1/MAFbx and MuRF1, are increased, while expression of proteins associated with protein synthesis, including AKT/mTOR, decreases (70,137,164)

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For the adults 60, the people who were homozygous for one of the polymorphisms (31% of the population studied) had average MMA levels of 420 nmol/l