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These alterations activate TLR-expressing glial cells, triggering chronic sterile inflammation that promotes neuronal loss and disrupts brain networks, ultimately leading to volume reduction in critical regions like the frontal lobe and hippocampus and contributing to cognitive impairment [369]

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Polarized macrophages were stimulated with 500 nM PMA at 37 C for 23 h and washed three times in RPMI 1640

All participants received 13 extracorporeal shock wave lithotripsy sessions

Ni C, Chiu MW