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The trial achieved its primary endpoints by demonstrating a statistically significant and superior improvement in liver fibrosis with no worsening of steatohepatitis, as well as resolution of steatohepatitis with no worsening of liver fibrosis with semaglutide 2.4 mg compared to placebo
That model tends to appeal to: self-pay patients comparing monthly total cost patients comfortable with compounding when appropriate people who want direct, ongoing dietitian access patients who care more about a specialized weight-loss workflow than a general PCP relationship Neither model is inherently "better" in every situation
The absorption rate from abdominal subcutaneous tissue tends to be the most consistent across different body compositions
Why It Matters for Patients Stronger satiety signals: Patients feel full sooner and may find it easier to stick with smaller meals
Tirzepatide can cause nausea and reduced food intake, which may lead to mild dehydration
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