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Regulation of ERK1 and ERK2 by glucose and peptide hormones in pancreatic beta cells
"This work not only highlights the potential off-target effect of semaglutide as an effective drug to treat metabolic osteoarthritis," the team from China and the US writes in their published paper, "but also reveals a weight loss-independent repair mechanism." In addition to mouse experiments, the researchers also conducted a randomized human trial to assess the effects of semaglutide on pain, mobility, and tissue degradation in individuals with osteoarthritis and obesity
Liu H-L, Luo R et al (2015) Identification and simultaneous quantification of five alkaloids in Piper longum L
Semaglutide works by increasing insulin secretion, decreasing glucagon secretion, slowing gastric emptying, and promoting a feeling of fullness (satiety)
Peptides degrade when exposed to heat, light, or contamination
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