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Circulation 138, 29082918
Of these, 74.7% were aware of their condition, 70.9% received antidiabetic treatment, and only 32.4% achieved glycosylated hemoglobin (HbA1c) 50%, and 15%25% of patients with diabetes experience neuropathic pain, referred to as painful DPN. Appropriate treatment of painful DPN is important because this pain contributes to a poor quality of life by causing sleep disturbance, anxiety, and depression
Its efficacy is demonstrated through the reduction of liver fat, improvement of liver function markers, and regulation of specific genes such as Atf3 and Acox2, supporting its development as a targeted therapy (82)
Conversely, if you tolerate the dose well but experience no appetite change by week 4, your provider may explore whether a faster escalation or higher starting dose aligns with your clinical profile
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