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Our findings indicate that the loss of dopaminergic neurons would start a vicious cycle of decreased dopamine releaseDRD2 signaling deficiencydecreased GSH synthesisoxidative stressdopaminergic neuron death during the progression of PD and explain the mechanism by which GSH decreases in the brains of PD patients (Supplementary Fig
Pistone G, Marino A, Leotta C, et al
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