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Vecchiarelli et al., 2021)
Bioinformatics 16 , 404405 (2000)
Complementary clinical and meta-analytic data consistently demonstrate systemic redox imbalance, including lower glutathione reserves, altered GSH/GSSG ratios, increased lipid peroxidation, and dysregulated NRF2 signaling, linking oxidative status to immune activation and synaptic dysfunction (James et al., 2004
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1 H-MRS is a noninvasive approach that enables the determination of in vivo concentrations of specific neurochemicals, including GSH
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