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International Journal of Toxicology, *37*(Suppl
Long-term toxicity test Over a relatively long period of time, different doses of CJC 1295 were administered to the experimental animals to observe its effects on the growth, metabolism, reproduction and immune system of the animals
waf1/cip1 , proapoptotic protein Bax-1 and cleaved caspase 3 but also reversed the increase in the cell proliferation markers including cyclin D1 and PCNA, suggesting that lycopene protects the gastric mucosa from smoking-induced damage through p53-dependent cell cycle control and apoptosis, and may counteract the development of gastric cancer associated with smoking (Liu et al., 2006) (Figure 3)
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