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Cooperative role of the glucagon-like peptide-1 receptor and 3-adrenergic-mediated signalling on fat mass reduction through the downregulation of PKA/AKT/AMPK signalling in the adipose tissue and muscle of rats
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Under high glucose conditions, GLP-1 at 100 nM enhanced the expression of osteogenic markers (collagen type I ( COL1 ), osteocalcin ( OCN ), runt-related transcription factor 2 ( RUNX2 ) and activated the Wingless-type MMTV integration site family member ( Wnt )/-catenin pathway, known to play a key role in osteogenesis, as shown by Li et al
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In clinical trials, the most substantial weight loss results were often seen in the first 20 to 30 weeks of treatment
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