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Semaglutide, the active ingredient in Ozempic and Wegovy, is a modified version of human GLP-1
It was not until January 2025 that the Ozempic label was updated to state that the drug is "not recommended in patients with severe gastroparesis." Even then, the label does not state that the drug itself may cause the condition
J Clin Endocrinol Metab1964 Oct;24:1076-82
References 1 AbbasG.HaqQ
We confirmed that all of the PSCs in both quiescent and activated state expressed GLP-1R with nuclear staining (Supplementary Figure S1)
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