Introduction Antipsychotic-induced weight gain (AIWG) contributes significantly to the 2-3-fold higher rates of obesity seen amongst those living with a severe mental illness (SMI) ( where lifestyle interventions and/or switching psychotropic medication do not appear successful, adjunctive metformin may be considered
Tirzepatide is the agonist of GLP-1 receptor and glucose-dependent insulinotropic polypeptide (GIP) receptor, which can reduce body weight and improve cardiac metabolism by subcutaneous injection once a week (Jastreboff et al 2022)
By Francesca Alfano, MS, CDN, CNS, IFNCP Protein Intake on GLP-1 Medications: How Much You Need and How to Get Enough GLP-1 medications such as semaglutide (Wegovy, Ozempic) and tirzepatide (Zepbound, Mounjaro) are increasingly used for weight loss and blood sugar management
They also slow down digestion, which adds to feelings of fullness and further reduces appetite
Those compounded options were meant as a temporary solution during a difficult time and were gradually phased out once the shortage ended