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Mice studies do show that they live longer when given supplemental melatonin over the course of their lives, starting in adulthood.[ref][ref][ref][ref] Animal studies also show that melatonin supplementation (beginning in middle to old age) prevents the decrease in bone mass associated with aging.[ref] It also increases mitochondrial function.[ref] Melatonin is necessary to reap the benefits of exercise when aging.[ref] Supplemental melatonin also doubles insulin sensitivity in older animals.[ref] We dont do human studies on chronic calorie restriction to extend lifespan nor have there been long-term studies in humans on supplemental melatonin for fifty-plus years to know the effect

Unlike stimulants, theres no jitteriness, insomnia (DSIP actually improves sleep), appetite suppression, or cardiovascular strain

However, both phenotypes exhibit lower growth in BSF, as BSF cultures required triple the liquid volumes and number of agar plates to produce cultures of similar cells numbers to those grown in LB ( S3 Fig ) (8) and fewer total metabolites were detected

Its not about numbing the skinmore like helping it get back to a stable baseline

Their cyclic structure provides exceptional stability, and the ability to administer them orally is a significant practical advantage