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Nakamura T, Iwanaga Y, Miyaji Y, Nohara R, Ishimura T, Miyazaki S, et al

However, due to the insufficient evaluation of the safety and long-term efficacy of Melanotan 2, its clinical application still requires caution

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Overall risk of bias for the primary outcome was low in all studies

Products marketed as oral GH secretagogues, growth hormone releasers, or peptide supplements generally contain amino acid precursors like arginine, lysine, and ornithine, which have modest effects on GH in very specific fasted conditions but nothing close to what a prescribed injectable peptide protocol achieves