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In prediabetes, metformin has evidence for delaying progression to type 2 diabetes in selected higher-risk groups, such as younger adults with higher body weight or people with a history of gestational diabetes
[166] Both alcohol and mirtazapine can cause sedation, drowsiness, and impaired cognitive function, and the combination may result in excessive sedation, increased risk of falls, and impaired judgment
The degree to which any of these factors impacted weight loss or glycemic control outcomes was not assessed in this study, but it is likely that variation in the therapeutic regimens pursued by the treatment group in order to reach desired outcomes impacted their trajectory, and could diminish the real-world effectiveness of these therapies
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GLP-1 medications can be effective for weight management because of their appetite-suppressing effects, which may lead to meaningful weight loss over time
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