Timestamps 00:00:00 Cold open: the man who couldnt stop gaining weight 00:01:49 Meet the case (and the rules of the game) 00:02:36 The presentation: 21, headaches, unexplained weight gain 00:03:57 Austins one-liner and how a clinician builds a differential 00:05:10 Secondary headaches: what raises the red flag 00:13:12 The exam: vitals, and the eye findings that matter 00:14:37 The labs, one number at a time 00:16:08 Raised pressure and a visual-field clue (bitemporal hemianopia) 00:20:45 The MRI 00:21:54 First diagnosis: craniopharyngioma 00:25:32 The name: a tumor built from tooth tissue 00:25:50 Surgery, and what it costs 00:27:43 The new mystery: gaining weight faster than ever 00:33:41 Second diagnosis: acquired hypothalamic obesity 00:39:17 How your brain sets your weight: the POMC brake and the AgRP accelerator 00:42:07 What about leptin
It is naturally found in many animal products and in oral and injectable supplements
-lipoic acid treatment (600 mg/day) has also demonstrated to improve neuropathic symptoms (pain, burning, paresthesia, and numbness) and deficits in patients with NP (Tesfaye, 2011)
Nucleic Acids Res 47:W171W174 Lee DY, Arnott D, Brown EJ (2013) Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery
"So, she went into drastic measures." Trish was on Ozempic before switching to Saxenda, a liraglutide injectable that helps with chronic weight management, according to Roy