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The adducts were screened by the sitting-drop vapour diffusion method using commercially available screens from Molecular Dimensions and Qiagen, dispensed by the Mosquito robot (TTP Labtech)
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Elevated serum UA levels also aggregate in blood vessels and carotid plaques, contributing to plaque vulnerability and eventual rupture
The catch is that the effect requires consistent, high-dose exposure, fades when treatment stops, and works very unevenly between individuals
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